Pharmacokinetics of Caspofungin in Burn Patients

Summary

Drug pharmacokinetics of antimicrobial agents is significantly altered in the burn patients. Additionally, burn patient population exhibits a wide inter- and intrapatient variation in drug handling. Several investigations carried out in burn patients treated with e.g. fluconazole showed the requirement to increase daily dose in comparison with healthy volunteers. However, no pharmacokinetic data are available of caspofungin in the burn population. The aim of this investigation is to investigate pharmacokinetics of caspofungin in burn patients after a single usual dose (70 mg i.v.), in order to determine the optimal dose in this population.

Timeline

Start

2009-02

Primary completion

2010-02

Completion

2010-12

Publications

• Results Jullien V, Blanchet B, Benyamina M, Tod M, Vinsonneau C. Pharmacokinetics of caspofungin in two patients with burn injuries. Antimicrob Agents Chemother. 2012 Aug;56(8):4550-1. doi: 10.1128/AAC.00039-12. Epub 2012 May 14. No abstract available.

Drugs

Indications

No indication recorded.