Cognitive Effects of Oral Oxybutynin and Oxybutynin Chloride Topical Gel in Older Volunteers

NCT00752141 ↗

Phase 1 Completed 153 enrolled Watson Pharmaceuticals

RandomizedParallel-groupTriple-blind

Summary

The purpose of this study is to explore the possible cognitive effects of oxybutynin tablets and oxybutynin gel.

Timeline

Start: 2008-09
Primary completion: 2008-10
Completion: —

Outcome

Missed primary endpoint

paper NFAT Delayed Recall tests revealed no significant treatment differences (overall, p = 0.2733; OTG vs placebo, p = 0.1551; OXB-IR vs placebo, p = 0.1767). PMID 22909146 ↗

Publications

Kay GG, Staskin DR, MacDiarmid S, McIlwain M, Dahl NV. Cognitive effects of oxybutynin chloride topical gel in older healthy subjects: a 1-week, randomized, double-blind, placebo- and active-controlled study. Clin Drug Investig. 2012 Oct 1;32(10):707-14. doi: 10.1007/BF03261924.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Oxybutynin	Small molecule	5 mg	Oral
Subject	Oxybutynin	Small molecule	100 mg	Oral

Indications

No indication recorded.