American Ginseng Treatment for Multiple Sclerosis Related Fatigue

Phase 2 Completed 56 enrolled Oregon Health and Science University National Multiple Sclerosis Society · collab

RandomizedCrossoverQuadruple-blindTreatment

Summary

This research project will determine the safety and tolerability of ginseng in subjects with MS and will gather preliminary data on the efficacy of ginseng vs placebo for the treatment of MS fatigue.

Timeline

Start: 2005-09
Primary completion: 2008-09
Completion: 2011-03

Outcome

Missed primary endpoint

paper fatigue on ginseng, as assessed by the Fatigue Severity Scale, was not significantly different from fatigue on placebo. PMID 21803872 ↗

Publications

Results Kim E, Cameron M, Lovera J, Schaben L, Bourdette D, Whitham R. American ginseng does not improve fatigue in multiple sclerosis: a single center randomized double-blind placebo-controlled crossover pilot study. Mult Scler. 2011 Dec;17(12):1523-6. doi: 10.1177/1352458511412062. Epub 2011 Jul 29.
Kim E, Lovera J, Schaben L, Melara J, Bourdette D, Whitham R. Novel method for measurement of fatigue in multiple sclerosis: Real-Time Digital Fatigue Score. J Rehabil Res Dev. 2010;47(5):477-84. doi: 10.1682/jrrd.2009.09.0151.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	GINSENG, AMERICAN	Unknown	400 mg	Oral