Effect of Intranasal Corticosteroids on Systemic Allergen Specific IgE

Summary

Evaluation of the effect of fluticasone propionate vs placebo applied as nasal spray on the increase of allergen-specific serum IgE levels following nasal exposure to recombinant allergens. Nasal sprays will be applied for four weeks starting two weeks before nasal provocation and serum IgE levels will be followed during eight weeks after nasal provocation.

Timeline

Start

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Primary completion

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Completion

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Outcome

Missed primary endpoint

paper There were no significant differences regarding the boosts of allergen-specific IgE between INCS- and placebo-treated subjects. PMID 25705889 ↗

Publications

• Egger C, Lupinek C, Ristl R, Lemell P, Horak F, Zieglmayer P, Spitzauer S, Valenta R, Niederberger V. Effects of nasal corticosteroids on boosts of systemic allergen-specific IgE production induced by nasal allergen exposure. PLoS One. 2015 Feb 23;10(2):e0114991. doi: 10.1371/journal.pone.0114991. eCollection 2015.

Drugs

Indications