drugset / Trial / NCT00755898
Urinary Excretion of Acetylamantadine by Cancer Patients
Phase 2
Completed
150 enrolled
University of Manitoba
BioMark Technologies Inc. · collabCanadian Institutes of Health Research (CIHR) · collab
Non-randomizedParallel-groupOpen-labelDiagnostic
Summary
The investigators have determined that the drug amantadine hydrochloride is metabolized by acetylation by a specific enzyme named spermidine/spermine N-acetyltransferase (SSAT). This enzyme is increased in cancer cells. The investigators hypothesized that the amount of N-acetylamantadine excreted in urine during the first 12 hours after an oral dose would serve as a diagnostic biomarker for the presence of cancer in a human test subject.
Timeline
- Start
- 2003-12
- Primary completion
- 2008-06
- Completion
- 2008-07
Publications
- Background Bras AP, Janne J, Porter CW, Sitar DS. Spermidine/spermine n(1)-acetyltransferase catalyzes amantadine acetylation. Drug Metab Dispos. 2001 May;29(5):676-80.
- Background Bras AP, Hoff HR, Aoki FY, Sitar DS. Amantadine acetylation may be effected by acetyltransferases other than NAT1 or NAT2. Can J Physiol Pharmacol. 1998 Jul-Aug;76(7-8):701-6. doi: 10.1139/cjpp-76-7-8-701.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Amantadine | Unknown | 200 mg | Oral |