Lowering Serum Uric Acid to Prevent Acute Kidney Injury

Phase 2 Completed 26 enrolled University of Florida

RandomizedParallel-groupQuadruple-blindPrevention

Summary

Acute kidney injury is associated with a rise in serum uric acid during cardiovascular surgery and can cause poor blood flow to the kidneys making them vulnerable to kidney injury. We hypothesize that hyperuricemia, particularly if chronic and marked, is a risk factor for acute kidney injury. The preoperative lowering of serum uric acid will reduce the incidence of acute kidney injury following cardiovascular surgery.

Timeline

Start: 2008-10
Primary completion: 2011-07
Completion: 2011-08

Publications

Background Ejaz AA, Mu W, Kang DH, Roncal C, Sautin YY, Henderson G, Tabah-Fisch I, Keller B, Beaver TM, Nakagawa T, Johnson RJ. Could uric acid have a role in acute renal failure? Clin J Am Soc Nephrol. 2007 Jan;2(1):16-21. doi: 10.2215/CJN.00350106. Epub 2006 Dec 6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Rasburicase	Protein / enzyme biologic	7.5 mg	Intravenous

Indications

No indication recorded.