Memantine as Adjunctive Therapy for Schizophrenia Negative Symptoms

Summary

Memantine as an add-on therapy to clozapine may improve schizophrenia negative symptoms and cognitive functioning.

Timeline

Start

2006-01

Primary completion

2008-01

Completion

2008-03

Publications

• de Lucena D, Fernandes BS, Berk M, Dodd S, Medeiros DW, Pedrini M, Kunz M, Gomes FA, Giglio LF, Lobato MI, Belmonte-de-Abreu PS, Gama CS. Improvement of negative and positive symptoms in treatment-refractory schizophrenia: a double-blind, randomized, placebo-controlled trial with memantine as add-on therapy to clozapine. J Clin Psychiatry. 2009 Oct;70(10):1416-23. doi: 10.4088/JCP.08m04935gry.

Drugs

Indications