drugset / Trial / NCT00758368
Comparison of Continuous and Pulsatile Apomorphine in Parkinson's Disease
Phase 2
Withdrawn
Oregon Health and Science University
National Institute of Neurological Disorders and Stroke (NINDS) · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to compare the effects of apomorphine, given by two different methods, to determine how best to manage dyskinesias.
Timeline
- Start
- 2009-03
- Primary completion
- 2011-06
- Completion
- 2011-06
Publications
- Background Manson AJ, Turner K, Lees AJ. Apomorphine monotherapy in the treatment of refractory motor complications of Parkinson's disease: long-term follow-up study of 64 patients. Mov Disord. 2002 Nov;17(6):1235-41. doi: 10.1002/mds.10281.
- Background Stocchi F, Ruggieri S, Vacca L, Olanow CW. Prospective randomized trial of lisuride infusion versus oral levodopa in patients with Parkinson's disease. Brain. 2002 Sep;125(Pt 9):2058-66. doi: 10.1093/brain/awf214.
- Background Stocchi F, Vacca L, Ruggieri S, Olanow CW. Intermittent vs continuous levodopa administration in patients with advanced Parkinson disease: a clinical and pharmacokinetic study. Arch Neurol. 2005 Jun;62(6):905-10. doi: 10.1001/archneur.62.6.905.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Apomorphine | Unknown | 20 mg | Subcutaneous |
| Subject | Apomorphine | Unknown | 100 mg | Subcutaneous |