Comparative Efficacy and Tolerability of Quetiapine XR and Amitriptyline in the Treatment of Fibromyalgia

Phase 4 Completed 90 enrolled University of Granada AstraZeneca · collab Hospital Clinico Universitario San Cecilio · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

Quetiapine, a second generation antipsychotic, has shown beneficial activity on fibromyalgia symptomatology, administered as add-on treatment, in a sample of 35 patients. The purpose of the present study is to compare, in a controlled setting, the efficacy and the tolerability of quetiapine extended release with amitriptyline in the treatment of patients with fibromyalgia

Timeline

Start: 2008-11
Primary completion: 2010-03
Completion: 2010-10

Publications

Background Hidalgo J, Rico-Villademoros F, Calandre EP. An open-label study of quetiapine in the treatment of fibromyalgia. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):71-7. doi: 10.1016/j.pnpbp.2006.06.023. Epub 2006 Aug 4.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Amitriptyline	Small molecule	25 mg	—
Subject	Quetiapine	Small molecule	100 mg	—

Comparative Efficacy and Tolerability of Quetiapine XR and Amitriptyline in the Treatment of Fibromyalgia

Summary

Timeline

Publications

Drugs

Indications