Effects of Statins on Lower Extremity Arterial Function Assessed by Magnetic Resonance Imaging

Summary

Cholesterol-lowering drugs called statins improve the functioning of the endothelium, and help prevent heart disease. The investigators are testing whether statins improve endothelial function more in the arteries that have worse endothelium to begin with. One of the functions of the endothelium is to help control how blood vessels dilate (expand) or contract (narrow) in different situations. This affects how blood flows through those vessels. Magnetic resonance imaging (MRI) can be used to evaluate endothelial function in the arms and legs noninvasively.

Timeline

Start

2008-06

Primary completion

2012-07

Completion

2012-07

Drugs

Indications