Genetic Sources of Variability of the Adaptation of the Ventricular Repolarisation

Phase 1 Completed 997 enrolled Assistance Publique - Hôpitaux de Paris

NaSingle-groupOpen-labelTreatment

Summary

The main objective is to research for genetic factors involved in the extreme modifications of the QT interval of the electrocardiogram in answer to a pharmacological stimulation (sotalol) and physiological stimulation in the apparently normal general population. The phenotypic characterization, based on the ventricular repolarisation dynamics will be used aiming at term of the predictive genetic factors of the acquired long QT syndrome

Timeline

Start: 2008-02
Primary completion: 2012-03
Completion: 2012-03

Publications

Salem JE, Germain M, Hulot JS, Voiriot P, Lebourgeois B, Waldura J, Tregouet DA, Charbit B, Funck-Brentano C. GENomE wide analysis of sotalol-induced IKr inhibition during ventricular REPOLarization, "GENEREPOL study": Lack of common variants with large effect sizes. PLoS One. 2017 Aug 11;12(8):e0181875. doi: 10.1371/journal.pone.0181875. eCollection 2017.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	sotalol	Small molecule	80 mg	Oral

Indications

No indication recorded.