Influenza Vaccination in Hemodialysis Patients and Renal Transplant Recipients

Phase 4 Completed 407 enrolled Universitaire Ziekenhuizen KU Leuven

Parallel-groupOpen-labelTreatment

Summary

Disturbances of acquired immunity are considered to be responsible, at least partly, for the high infection rate and inadequate response to vaccinations observed in hemodialysis (HD) patients and renal transplant recipient (RTR). The present prospective trial aims at (a) evaluating the immunogenicity of a standard influenza vaccine in HD and RTR patients and (b) at identifying determinants of the immune response.

Timeline

Start: 2003-09
Primary completion: 2004-05
Completion: 2004-05

Publications

Scharpe J, Peetermans WE, Vanwalleghem J, Maes B, Bammens B, Claes K, Osterhaus AD, Vanrenterghem Y, Evenepoel P. Immunogenicity of a standard trivalent influenza vaccine in patients on long-term hemodialysis: an open-label trial. Am J Kidney Dis. 2009 Jul;54(1):77-85. doi: 10.1053/j.ajkd.2008.11.032. Epub 2009 Apr 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	trivalent split influenza vaccine	Vaccine	0.5 ml	Intramuscular

Indications

No indication recorded.