White Button Mushroom Extract in Treating Patients With Recurrent Prostate Cancer After Local Therapy

Phase 1 Completed 36 enrolled City of Hope Medical Center National Cancer Institute (NCI) · collab

NaSingle-groupOpen-labelTreatment

Summary

RATIONALE: White button mushroom extract may stop or delay the development of recurrent prostate cancer. PURPOSE: This phase I trial is studying the side effects and best dose of white button mushroom extract in treating patients with recurrent prostate cancer after local therapy.

Timeline

Start: 2009-01-29
Primary completion: 2021-06-10
Completion: 2021-06-10

Publications

Twardowski P, Kanaya N, Frankel P, Synold T, Ruel C, Pal SK, Junqueira M, Prajapati M, Moore T, Tryon P, Chen S. A phase I trial of mushroom powder in patients with biochemically recurrent prostate cancer: Roles of cytokines and myeloid-derived suppressor cells for Agaricus bisporus-induced prostate-specific antigen responses. Cancer. 2015 Sep 1;121(17):2942-50. doi: 10.1002/cncr.29421. Epub 2015 May 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	White Button Mushroom Extract	Other / unclassified	4 g	Oral
Subject	White Button Mushroom Extract	Other / unclassified	6 g	Oral
Subject	White Button Mushroom Extract	Other / unclassified	8 g	Oral
Subject	White Button Mushroom Extract	Other / unclassified	10 g	Oral
Subject	White Button Mushroom Extract	Other / unclassified	12 g	Oral
Subject	White Button Mushroom Extract	Other / unclassified	14 g	Oral

White Button Mushroom Extract in Treating Patients With Recurrent Prostate Cancer After Local Therapy

Summary

Timeline

Publications

Drugs

Indications