drugset / Trial / NCT00779259
Drug - Drug Interaction Study Between Quinine Sulfate and Theophylline
Non-randomizedSingle-groupOpen-labelBasic science
Summary
In a prior in vitro study using human hepatocytes quinine was shown to induce the activity of Cytochrome p450 CYP 1A2. The present study will evaluate the extent to which quinine sulfate-related induction of this enzyme effects the pharmacokinetics of theophylline, a sensitive probe drug for the activity of CYP 1A2. It will also evaluate the effect of single-dose theophylline on the pharmacokinetics of steady-state quinine sulfate.
Timeline
- Start
- 2007-08
- Primary completion
- 2007-09
- Completion
- 2007-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Quinine | Small molecule | 324 mg | Oral |
| Subject | Quinine | Small molecule | 648 mg | Oral |
| Comparator | Theophylline | Small molecule | 300 mg | Oral |
Indications
No indication recorded.