Autologous Serum Efficacy Study in Patients With Severe Dry Eye

Phase 2 Completed 12 enrolled University of Chile

RandomizedCrossoverQuadruple-blindTreatment

Summary

The purpose of this study is to compare the reduction in symptomatology of patients with severe dry eye treated with autologous serum and conventional artificial tears.

Timeline

Start: 2008-10
Primary completion: 2008-12
Completion: 2008-12

Outcome

Met primary endpoint

paper Autologous serum treatment showed a statistically significant (p = 0.002) higher OSDI decrease (50%) versus conventional treatment (22%). PMID 22670856 ↗

Publications

Urzua CA, Vasquez DH, Huidobro A, Hernandez H, Alfaro J. Randomized double-blind clinical trial of autologous serum versus artificial tears in dry eye syndrome. Curr Eye Res. 2012 Aug;37(8):684-8. doi: 10.3109/02713683.2012.674609. Epub 2012 Jun 6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Autologous serum	Unknown	20 %	Other
Subject	Systane	Other / unclassified	—	—