Comparative Study of Quinine Sulfate in Healthy Patients and in Patients With Renal Impairment

Summary

The effects of mild or moderate renal impairment (creatinine clearance 30 to 50 ml/min or \>50 to 80 ml/min, respectively) on the pharmacokinetic profile of quinine and its active metabolite, 3'-hydroxyquinine, will be investigated. Safety and tolerability in healthy subjects versus those with mild to moderate renal impairment will be compared, as well.

Timeline

Start

2007-11

Primary completion

2011-01

Completion

2011-01

Drugs

Indications