A Study of MK0663/Etoricoxib for Post-Abdominal Hysterectomy Surgery Pain (0663-097)(COMPLETED)

Summary

The purpose of this study is to evaluate the efficacy and safety of etoricoxib compared to placebo in the treatment of postoperative pain associated with total abdominal hysterectomy.

Timeline

Start

2008-10

Primary completion

2010-07

Completion

2010-07

Outcome

Met primary endpoint

registry analysis (unspecified test); Etoricoxib 120 mg vs Placebo; p <0.001; ANOVA NCT00788710 ↗

registry analysis (unspecified test); Etoricoxib 90 mg vs Placebo; p <0.001; ANOVA NCT00788710 ↗

Publications

• Viscusi ER, Frenkl TL, Hartrick CT, Rawal N, Kehlet H, Papanicolaou D, Gammaitoni A, Ko AT, Morgan LM, Mehta A, Curtis SP, Peloso PM. Perioperative use of etoricoxib reduces pain and opioid side-effects after total abdominal hysterectomy: a double-blind, randomized, placebo-controlled phase III study. Curr Med Res Opin. 2012 Aug;28(8):1323-35. doi: 10.1185/03007995.2012.707121. Epub 2012 Jul 16.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Etoricoxib	Small molecule	90 mg	—
Subject	Etoricoxib	Small molecule	120 mg	—

Indications