Heliox in Experimental Upper Airway Obstruction

Phase 1/2 Completed 44 enrolled University of Witten/Herdecke

RandomizedCrossoverQuadruple-blindTreatment

Summary

Currently it is common medical wisdom that HELIOX (mixture of Helium in Oxygen) with a fraction of Helium below 60% is not effective in reducing airway obstruction. The investigators test the hypothesis that HELIOX with a fraction of Helium below 60% is still effective in relieving airway obstruction in a double-blind, randomized and controlled clinical PoC study with experimental upper airway obstruction.

Timeline

Start: 2007-11
Primary completion: 2007-12
Completion: —

Publications

Truebel H, Wuester S, Boehme P, Doll H, Schmiedl S, Szymanski J, Langer T, Ostermann T, Cysarz D, Thuermann P. A proof-of-concept trial of HELIOX with different fractions of helium in a human study modeling upper airway obstruction. Eur J Appl Physiol. 2019 May;119(5):1253-1260. doi: 10.1007/s00421-019-04116-7. Epub 2019 Mar 8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Heliox	Other / unclassified	25 %	Inhaled
Comparator	Heliox	Other / unclassified	50 %	Inhaled
Comparator	Heliox	Other / unclassified	75 %	Inhaled

Indications

No indication recorded.