A Study of the Pharmacokinetics of Paliperidone in Volunteers With Normal or Impaired Liver Function

Summary

The purpose of this study is 1) to investigate the single-dose pharmacokinetics of immediate release (IR) paliperidone, after oral administration, in patients having moderate hepatic impairment compared to patients having normal hepatic function, 2) to document the plasma protein binding and disposition of the enantiomers of paliperidone, and 3) to evaluate the tolerability and safety profile of IR paliperidone in both patient populations.

Timeline

Start

2004-08

Primary completion

—

Completion

2004-12

Drugs

Indications