Pilot Trial of Naltrexone for Obesity in Women With Schizophrenia

Completed 24 enrolled Yale University Ethel F. Donaghue Women's Health Investigator Program at Yale · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this clinical trial is to find out how effective low dose oral naltrexone is on reducing body weight when compared to placebo in women with schizophrenia and schizoaffective disorder.

Timeline

Start: 2008-12
Primary completion: 2010-11
Completion: 2010-11

Publications

Results Tek C, Ratliff J, Reutenauer E, Ganguli R, O'Malley SS. A randomized, double-blind, placebo-controlled pilot study of naltrexone to counteract antipsychotic-associated weight gain: proof of concept. J Clin Psychopharmacol. 2014 Oct;34(5):608-12. doi: 10.1097/JCP.0000000000000192.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Naltrexone	Small molecule	25 mg	Oral

Pilot Trial of Naltrexone for Obesity in Women With Schizophrenia

Summary

Timeline

Publications

Drugs

Indications