drugset / Trial / NCT00795210
Effects of Short-term Growth Hormone in HIV-infected Patients
Completed
25 enrolled
Massachusetts General Hospital
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to examine the short-term effects of two different doses of growth hormone, compared to treatment with growth hormone releasing hormone, on the brain's secretion of growth hormone and the body's glucose metabolism. We hypothesize that growth hormone administration will alter the body's endogenous pulsatile growth hormone secretion and that higher dose growth hormone may decrease insulin sensitivity. We hypothesize that growth hormone releasing hormone will augment endogenous GH pulsatility and be neutral to insulin sensitivity.
Timeline
- Start
- 2009-02
- Primary completion
- 2012-11
- Completion
- 2012-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Somatropin | Protein / enzyme biologic | 6 ug/kg | Subcutaneous |
| Subject | Somatropin | Protein / enzyme biologic | 2 mg | Subcutaneous |
| Subject | Tesamorelin | Peptide | 2 mg | Subcutaneous |