drugset / Trial / NCT00795210

Effects of Short-term Growth Hormone in HIV-infected Patients

NCT00795210

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to examine the short-term effects of two different doses of growth hormone, compared to treatment with growth hormone releasing hormone, on the brain's secretion of growth hormone and the body's glucose metabolism. We hypothesize that growth hormone administration will alter the body's endogenous pulsatile growth hormone secretion and that higher dose growth hormone may decrease insulin sensitivity. We hypothesize that growth hormone releasing hormone will augment endogenous GH pulsatility and be neutral to insulin sensitivity.

Timeline

Start
2009-02
Primary completion
2012-11
Completion
2012-11

Drugs

EvaluationDrugModalityDoseRoute
Subject Somatropin Protein / enzyme biologic 6 ug/kg Subcutaneous
Subject Somatropin Protein / enzyme biologic 2 mg Subcutaneous
Subject Tesamorelin Peptide 2 mg Subcutaneous

Indications