drugset / Trial / NCT00799604

Clevidipine Bolus Administration in the Treatment of Hypertensive Patients Undergoing Cardiac Surgery (SPRINT)

NCT00799604

Phase 2 Completed 30 enrolled The Medicines Company
NaSingle-groupOpen-labelTreatment

Summary

This study was designed to evaluate the pharmacodynamics of a bolus dosing regimen of clevidipine, a vascular-selective L-type calcium channel antagonist, for the management of blood pressure in cardiac surgery patients, as well as to evaluate the efficacy, safety and pharmacokinetics of clevidipine after bolus administration.

Timeline

Start
2008-11
Primary completion
2009-10
Completion
2009-10

Drugs

EvaluationDrugModalityDoseRoute
Subject Clevidipine Small molecule 125 ug Intravenous
Subject Clevidipine Small molecule 250 ug Intravenous
Subject Clevidipine Small molecule 500 ug Intravenous

Indications