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drugset / Trial / NCT00805454

Positron Emission Tomagraphy (PET) Study Following a Single Oral Dose of OPC-34712

NCT00805454 ↗

Phase 1 Completed 15 enrolled Otsuka Pharmaceutical Development & Commercialization, Inc. Otsuka Pharmaceutical Co., Ltd. · collab

Open-labelBasic science

Summary

Determine the degree of striatal D2 receptor occupancy induced by OPC-34712 at differenht dose levels in healthy volunteers.

Timeline

Start: 2008-12
Primary completion: 2009-07
Completion: 2009-07

Publications

Wong DF, Raoufinia A, Bricmont P, Brasic JR, McQuade RD, Forbes RA, Kikuchi T, Kuwabara H. An open-label, positron emission tomography study of the striatal D2/D3 receptor occupancy and pharmacokinetics of single-dose oral brexpiprazole in healthy participants. Eur J Clin Pharmacol. 2021 May;77(5):717-725. doi: 10.1007/s00228-020-03021-9. Epub 2020 Nov 16.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Brexpiprazole	Small molecule	0.5 mg	Oral
Subject	Brexpiprazole	Small molecule	25 mg	Oral

Indications