Radioimmunoimaging of AL Amyloidosis

Phase 1 Completed 40 enrolled University of Tennessee FDA Office of Orphan Products Development · collab

NaSingle-groupOpen-labelDiagnostic

Summary

The purpose of the study is to determine the capability of a radiolabeled amyloid-reactive monoclonal antibody to document the presence and distribution of amyloid deposits by PET/CT imaging in patients with AL amyloidosis.

Timeline

Start: 2008-12
Primary completion: 2012-03
Completion: 2013-07

Publications

Wall JS, Kennel SJ, Stuckey AC, Long MJ, Townsend DW, Smith GT, Wells KJ, Fu Y, Stabin MG, Weiss DT, Solomon A. Radioimmunodetection of amyloid deposits in patients with AL amyloidosis. Blood. 2010 Sep 30;116(13):2241-4. doi: 10.1182/blood-2010-03-273797. Epub 2010 Jun 3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	MU-11-1F4 124I	Monoclonal antibody	1 mg	Intravenous
Subject	MU-11-1F4 124I	Monoclonal antibody	74 mbq	Intravenous

Radioimmunoimaging of AL Amyloidosis

Summary

Timeline

Publications

Drugs

Indications