8 Weeks Study to Evaluate the Efficacy and Safety of Valsartan in Combination With Aliskiren Compared to Valsartan Alone in Patients With Stage 2 Hypertension

Summary

To evaluate the efficacy and safety of the valsartan/aliskiren combination compared to valsartan alone in patients with Stage 2 hypertension.

Timeline

Start

2009-01

Primary completion

2009-07

Completion

2009-07

Outcome

Missed primary endpoint

registry analysis (superiority or other test); Valsartan/Aliskiren vs Valsartan; p = 0.295; Least Square Mean Difference -1.6 (95% CI -4.61 to 1.40); ANCOVA NCT00809926 ↗

Publications

• Flack JM, Yadao AM, Purkayastha D, Samuel R, White WB. Comparison of the effects of aliskiren/valsartan in combination versus valsartan alone in patients with stage 2 hypertension. J Am Soc Hypertens. 2012 Mar-Apr;6(2):142-51. doi: 10.1016/j.jash.2011.11.004. Epub 2012 Feb 9.

Drugs

Indications