Treatment of Insomnia in Migraineurs

Summary

It is hypothesized that treating insomnia in migraineurs, many of whom also have tension headaches, prolongs total sleep time to the extent that it decreases overall headache frequency. Chronic headache sufferers also feel more tired during the day, undoubtedly affecting daytime functioning, which is hypothesized to improve as well with prolonged total sleep time.

Timeline

Start

2007-04

Primary completion

2008-09

Completion

2008-09

Outcome

Missed primary endpoint

paper The study did not meet primary endpoint PMID 25323219 ↗

registry analysis (superiority test); Eszoplicone 3mg vs Placebo; p = 0.33; t-test, 2 sided NCT00812214 ↗

Publications

• Results Spierings EL, McAllister PJ, Bilchik TR. Efficacy of treatment of insomnia in migraineurs with eszopiclone (Lunesta(R)) and its effect on total sleep time, headache frequency, and daytime functioning: A randomized, double-blind, placebo-controlled, parallel-group, pilot study. Cranio. 2015 Apr;33(2):115-21. doi: 10.1179/0886963414Z.00000000084. Epub 2014 Oct 16.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Eszopiclone	Small molecule	3 mg	—

Indications