Study of Statin as Neo-Adjuvant Therapy in Postmenopausal Breast Cancer

Summary

The purpose of this study is to monitor: * Tumor biological alterations following two weeks of neo-adjuvant statin therapy. * Effects of statins on tumor proliferation. * Functional studies on the mevalonate pathway.

Timeline

Start

2009-01

Primary completion

2012-03

Completion

2012-03

Publications

• Feldt M, Menard J, Rosendahl AH, Lettiero B, Bendahl PO, Belting M, Borgquist S. The effect of statin treatment on intratumoral cholesterol levels and LDL receptor expression: a window-of-opportunity breast cancer trial. Cancer Metab. 2020 Nov 23;8(1):25. doi: 10.1186/s40170-020-00231-8.
• Feldt M, Bjarnadottir O, Kimbung S, Jirstrom K, Bendahl PO, Veerla S, Grabau D, Hedenfalk I, Borgquist S. Statin-induced anti-proliferative effects via cyclin D1 and p27 in a window-of-opportunity breast cancer trial. J Transl Med. 2015 Apr 29;13:133. doi: 10.1186/s12967-015-0486-0.

Drugs

Indications