Cholera Toxin B Subunit (CTB) Administered by Mucosal Way in Healthy Adult Volunteer

Summary

It is a biomedical research without direct individual benefit, exploring and comparing the mucosal immune response after oral, nasal and sublingual administration of B-subunit of non-toxic cholera toxin (CTB) in healthy adult volunteers.

Timeline

Start

2006-04

Primary completion

2006-04

Completion

2007-02

Publications

• Results Cuburu N, Kweon MN, Song JH, Hervouet C, Luci C, Sun JB, Hofman P, Holmgren J, Anjuere F, Czerkinsky C. Sublingual immunization induces broad-based systemic and mucosal immune responses in mice. Vaccine. 2007 Dec 12;25(51):8598-610. doi: 10.1016/j.vaccine.2007.09.073. Epub 2007 Oct 25.

Drugs

Indications