Evaluation of Bacteria in the Mouth and Throat of Healthy Adults Before and After the Administration of Either Levofloxacin or Azithromycin, Both Antibiotic Medications

Phase 1 Completed 143 enrolled Ortho-McNeil Janssen Scientific Affairs, LLC

RandomizedParallel-groupOpen-labelTreatment

Summary

Evaluation of bacteria in the mouth and throat before study drug ( Levofloxacin, floroquinolone antibiotic and Azithromycin, a macrolide antibiotic) is started and then periodically for 6 weeks after the last dose of study drug is taken

Timeline

Start: 2006-06
Primary completion: —
Completion: 2006-09

Publications

Nord CE, Peterson J, Ambruzs M, Fisher AC. Levofloxacin versus azithromycin on the oropharyngeal carriage and selection of antibacterial- resistant streptococci in the microflora of healthy adults. Curr Med Res Opin. 2009 Jun;25(6):1461-7. doi: 10.1185/03007990902953468.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Azithromycin	Small molecule	250 mg	Oral
Subject	Levofloxacin	Small molecule	750 mg	Oral

Indications

No indication recorded.