Comparison of the Fixed Combinations of Brimonidine/Timolol and Dorzolamide/Timolol in Subjects With Open-Angle Glaucoma or Ocular Hypertension

NCT00822081 ↗

Phase 4 Completed 140 enrolled Bp Consulting, Inc Allergan · collab

RandomizedParallel-groupSingle-blindTreatment

Summary

This study compares the efficacy and tolerability/comfort of brimonidine/timolol and dorzolamide/timolol in patients with open-angle glaucoma or ocular hypertension. In an investigator masked randomization process, each subject is allocated to recieve either brimonidine/timolol or dorzolamide/timolol as fixed-combination monotherapy or as an adjuctive to a prostoglandin analogue for a period of 12 weeks. After screening, patient returns at baseline, Month 1, and Month 3 for ophthalmic evaluations.

Timeline

Start: 2005-01
Primary completion: 2006-04
Completion: 2006-04

Publications

Nixon DR, Yan DB, Chartrand JP, Piemontesi RL, Simonyi S, Hollander DA. Three-month, randomized, parallel-group comparison of brimonidine-timolol versus dorzolamide-timolol fixed-combination therapy. Curr Med Res Opin. 2009 Jul;25(7):1645-53. doi: 10.1185/03007990902994041.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	brimonidine tartrate 0.2%/timolol maleate 0.5% fixed combination	Unknown	0.2 %	Topical
Comparator	brimonidine tartrate 0.2%/timolol maleate 0.5% fixed combination	Unknown	0.5 %	Topical
Comparator	dorzolamide hcl 2%/ timolol maleate 0.5% fixed combination	Unknown	0.5 %	Topical
Comparator	dorzolamide hcl 2%/ timolol maleate 0.5% fixed combination	Unknown	2 %	Topical

Comparison of the Fixed Combinations of Brimonidine/Timolol and Dorzolamide/Timolol in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Summary

Timeline

Publications

Drugs

Indications