drugset / Trial / NCT00823004
Antagonist/Letrozole in Poor Responders
RandomizedParallel-groupOpen-labelTreatment
Summary
Failure to respond to controlled ovarian hyperstimulation (COH) is still a major concern in assisted reproduction and there is no consensus on the ovarian stimulation choice regime for poor responders. Aim: To evaluate and compare the efficacy of a microdose GnRH agonist flare (MF) and a GnRH antagonist/letrozole (A/L) protocols in poor responders undergoing in vitro fertilization (IVF). Methods: One hundred eighty poor responder patients will be randomized to an ovarian stimulation protocol with either a MF or a letrozole and high dose FSH/hMG and flexible GnRH antagonist protocol.
Timeline
- Start
- 2008-06
- Primary completion
- 2009-02
- Completion
- 2009-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Ganirelix | Protein / enzyme biologic | 0.25 mg | Subcutaneous |
| Comparator | Letrozole | Other / unclassified | 5 mg | — |
| Comparator | buserelin | Unknown | 50 ug | Subcutaneous |
| Comparator | Gonal-f | Protein / enzyme biologic | 300 iu | — |
| Comparator | Gonal-f | Protein / enzyme biologic | 450 iu | — |
| Comparator | Marvelone | Unknown | — | Oral |
| Comparator | Merional | Protein / enzyme biologic | 300 iu | — |
| Comparator | Merional | Protein / enzyme biologic | 450 iu | — |