drugset / Trial / NCT00824733

Agatolimod and Trastuzumab in Treating Patients With Locally Advanced or Metastatic Breast Cancer

NCT00824733

Phase 2 Terminated 6 enrolled Bhuvaneswari Ramaswamy Pfizer · collab
NaSingle-groupOpen-labelTreatment

Summary

RATIONALE: Biological therapies, such as agatolimod, may stimulate the immune system in different ways and stop tumor cells from growing. Monoclonal antibodies, such as trastuzumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Giving agatolimod together with trastuzumab may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving agatolimod together with trastuzumab works in treating patients with locally advanced or metastatic breast cancer.

Timeline

Start
2009-02
Primary completion
2013-02
Completion
2014-04

Drugs

EvaluationDrugModalityDoseRoute
Subject Trastuzumab Monoclonal antibody 2 mg/kg Intravenous
Subject agatolimod Oligonucleotide (other) 0.16 mg/kg Subcutaneous

Indications