drugset / Trial / NCT00825123
Effects of Heart Rate Reduction on Central Arterial Pressure in Healthy Individuals
RandomizedParallel-groupTriple-blindBasic science
Summary
The purpose of this project is to determine the effects of slowing heart rate upon both central and peripheral blood pressures using Ivabradine. The effects of Ivabradine will be compared to Metoprolol and placebo. Participants will attend the hospital for 3 visits where they will be randomised to receive either Ivabradine, Metoprolol and placebo on each visit. Non-invasive measures of blood pressure will be recorded before and after consuming the study drug.
Timeline
- Start
- 2008-10
- Primary completion
- 2011-11-08
- Completion
- 2011-11-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ivabradine | Small molecule | 10 mg | Oral |
| Comparator | Metoprolol | Other / unclassified | 50 mg | Oral |
Indications
No indication recorded.