Study on Tolerability of Levodopa/Carbidopa in Children With Angelman Syndrome

Summary

This study is designed to determine the highest dose of levodopa/carbidopa that can be tolerated without any serious side effects by children with Angelman syndrome. It has been hypothesized that levodopa may lead to an improvement in the neurodevelopment and abnormal movements (e.g. tremors) in children with Angelman syndrome. Data from this study will be used to design a phase II trial to determine the efficacy of levodopa in treating children with Angelman syndrome.

Timeline

Start

2009-01

Primary completion

2010-06

Completion

2010-06

Drugs

Indications