Adjunctive Atropine During Ketamine Sedation

Phase 4 Completed 140 enrolled Seoul National University Hospital

RandomizedParallel-groupQuadruple-blindTreatment

Summary

* Ketamine seems an obvious choice in the setting of an emergency department * Ketamine leads to increased production of salivary and tracheal secretions * Antisialagogues(atropine)therefore have been recommended as a routine adjunct * We compare atropine with placebo as an adjunct to ketamine sedation in children undergoing primary closure of lacerated wound

Timeline

Start: 2008-08
Primary completion: 2010-12
Completion: 2010-12

Publications

Kye YC, Rhee JE, Kim K, Kim T, Jo YH, Jeong JH, Lee JH. Clinical effects of adjunctive atropine during ketamine sedation in pediatric emergency patients. Am J Emerg Med. 2012 Nov;30(9):1981-5. doi: 10.1016/j.ajem.2012.04.030. Epub 2012 Jun 28.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Atropine	Other / unclassified	0.01 mg/kg	Intravenous
Background	Ketamine	Small molecule	2 mg/kg	Intravenous

Indications

No indication recorded.