drugset / Trial / NCT00837590
Vascular Function, Endothelin, and Inflammation in Pre-diabetic Obesity Versus Lean Healthy Controls
RandomizedParallel-groupOpen-labelTreatment
Summary
Aims: 1. Does inflammation contribute importantly to concurrent defects in vascular and metabolic dysfunction in human pre-diabetic obesity? 2. Are there benefits of anti-inflammatory treatment strategies in pre-diabetic obesity in the context of existing treatment with metformin? 3. Are there benefits of anti-inflammatory treatment strategies in pre-diabetic obesity in the context of existing treatment with lisinopril?
Timeline
- Start
- 2009-03
- Primary completion
- 2010-06
- Completion
- 2010-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Salsalate | Small molecule | 2 g | Oral |
| Subject | Salsalate | Small molecule | 4 g | Oral |