Bronchoscopy and Bispectral Index (BIS) - Guided Sedation

Phase 4 Completed 84 enrolled University Hospital, Geneva Centre Valaisan de Pneumologie, CH-3960Montana · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

Bronchoscopy is performed on a daily basis for diagnostic and therapeutic purposes. This procedure may cause anxiety and discomfort requiring the use of sedative drugs. In this study the investigators titrate the administration of sedatives using bispectral analysis of the EEG. The investigators compared 2 drugs, propofol versus midazolam regarding patient subjective tolerance, recovery of brain function, safety and operator's satisfaction.

Timeline

Start: 2005-01
Primary completion: 2007-11
Completion: 2007-12

Publications

Clark G, Licker M, Younossian AB, Soccal PM, Frey JG, Rochat T, Diaper J, Bridevaux PO, Tschopp JM. Titrated sedation with propofol or midazolam for flexible bronchoscopy: a randomised trial. Eur Respir J. 2009 Dec;34(6):1277-83. doi: 10.1183/09031936.00142108. Epub 2009 May 14.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Midazolam	Small molecule	2 mg	Intravenous
Comparator	Propofol	Small molecule	20 mg	Intravenous

Indications

No indication recorded.