drugset / Trial / NCT00845650

Safety and Pharmacokinetics Study of Anthrax Immune Globulin Intravenous (AIGIV)

NCT00845650

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to: * evaluate the safety profile of a single intravenous administration of AIGIV (containing either 3.5 mg/kg, 7.0 mg/kg or 14.0 mg/kg anti-PA IgG) as compared with either 90 mg/kg, 180 mg/kg or 360 mg/kg total IgG, GAMUNEX® (immune globulin intravenous (human) 10% caprylate/chromatography purified). GAMUNEX is a trademark of Talecris Biotherapeutics. * evaluate the pharmacokinetic (PK) profile of a single intravenous administration of AIGIV (containing either 3.5 mg/kg, 7.0 mg/kg or 14.0 mg/kg anti-PA IgG) as measured by lethal toxin neutralizing antibody (TNA).

Timeline

Start
2009-02
Primary completion
2010-10
Completion
2010-10

Drugs

EvaluationDrugModalityDoseRoute
Subject Anthrax Immune Globulin Intravenous Protein / enzyme biologic 3.5 mg/kg Intravenous
Subject Anthrax Immune Globulin Intravenous Protein / enzyme biologic 7 mg/kg Intravenous
Subject Anthrax Immune Globulin Intravenous Protein / enzyme biologic 14 mg/kg Intravenous
Subject Immune Globulin Intravenous (Human) Protein / enzyme biologic 90 mg/kg Intravenous
Subject Immune Globulin Intravenous (Human) Protein / enzyme biologic 180 mg/kg Intravenous
Subject Immune Globulin Intravenous (Human) Protein / enzyme biologic 360 mg/kg Intravenous

Indications