Exacerbation Study

Summary

This study compares indacaterol with tiotropium in terms of bronchodilation over 52 weeks

Timeline

Start

2009-03

Primary completion

2012-07

Completion

2012-07

Outcome

Met primary endpoint

paper The lower limit of the 97.5% CI was above the prespecified non-inferiority margin of -0.055 L, suggesting that indacaterol was non-inferior to tiotropium. PMID 24461613 ↗

Publications

• Decramer ML, Chapman KR, Dahl R, Frith P, Devouassoux G, Fritscher C, Cameron R, Shoaib M, Lawrence D, Young D, McBryan D; INVIGORATE investigators. Once-daily indacaterol versus tiotropium for patients with severe chronic obstructive pulmonary disease (INVIGORATE): a randomised, blinded, parallel-group study. Lancet Respir Med. 2013 Sep;1(7):524-33. doi: 10.1016/S2213-2600(13)70158-9. Epub 2013 Aug 21.

Drugs

Indications