Endothelial Function in Human Arteries

Phase 0 Completed 25 enrolled The Cleveland Clinic

NaSingle-groupOpen-labelTreatment

Summary

Up to 30 patients with lower extremity disease scheduled to undergo diagnostic angiography will undergo baseline bloodwork and IVUS (intravascular ultrasound), followed by dosing with L-arginine to assess changes in endothelial function.

Timeline

Start: 2009-09
Primary completion: 2011-01
Completion: 2011-01

Publications

Kashyap VS, Lakin RO, Campos P, Allemang M, Kim A, Sarac TP, Hausladen A, Stamler JS. The LargPAD Trial: Phase IIA evaluation of l-arginine infusion in patients with peripheral arterial disease. J Vasc Surg. 2017 Jul;66(1):187-194. doi: 10.1016/j.jvs.2016.12.127. Epub 2017 Mar 30.
Kashyap VS, Lakin RO, Feiten LE, Bishop PD, Sarac TP. In vivo assessment of endothelial function in human lower extremity arteries. J Vasc Surg. 2013 Nov;58(5):1259-66. doi: 10.1016/j.jvs.2013.05.029. Epub 2013 Jul 3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	L-arginine	Small molecule	50 mg	Other
Subject	L-arginine	Small molecule	100 mg	Other
Subject	L-arginine	Small molecule	500 mg	Other

Indications

No indication recorded.