Celecoxib for Pediatric Adenotonsillectomy

Phase 2 Completed 282 enrolled Children's Hospital of Eastern Ontario University of Ottawa · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The investigators' study will involve the administration of either placebo or celecoxib to children aged 2 to 18 years of age undergoing tonsillectomy and assessing pain relief, impact on quality of life and side effect profile.

Timeline

Start: 2009-08
Primary completion: 2012-08
Completion: 2012-12

Outcome

Met primary endpoint

paper 7 mm sur une EVA; intervalle de confiance [IC] 95 %: 0,3 à 14; P = 0,04 PMID 25846344 ↗

Publications

Murto K, Lamontagne C, McFaul C, MacCormick J, Ramakko KA, Aglipay M, Rosen D, Vaillancourt R. Celecoxib pharmacogenetics and pediatric adenotonsillectomy: a double-blinded randomized controlled study. Can J Anaesth. 2015 Jul;62(7):785-97. doi: 10.1007/s12630-015-0376-1. Epub 2015 Apr 7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Celecoxib	Other / unclassified	3 mg/kg	Oral