Pharmacodynamic (PD) Study of Intranodal Adenovirus-CD154 (Ad-ISF35) in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

Summary

Primary Objectives * To determine the safety and maximum tolerated dose (MTD) of Adenovirus-CD154 (Ad-ISF35) when it is injected directly into the lymph nodes of patients with CLL or SLL. Secondary Objectives * To determine and monitor clinical and biological responses in patients treated with injections of Ad-ISF35. * To determine how ISF35 works in CLL/SLL patients' cells.

Timeline

Start

2006-02

Primary completion

2009-10

Completion

2009-10

Drugs

Indications