drugset / Trial / NCT00860392

A Comparison of Measurements of Ketone Body Flux Versus Ketone Body Concentration as a Pharmacodynamic Marker of Hepatic Fatty Acid Oxidation (0000-110)

NCT00860392 ↗

Phase 1 Completed 24 enrolled Merck Sharp & Dohme LLC
Non-randomizedParallel-groupOpen-labelDiagnostic

Summary

This study will compare two approaches to the measurement of fatty acid oxidation (ketone body flux and ketone body concentration) and determine which method demonstrates superior sensitivity and variability in the detection of moderate increases in ketogenesis rates.

Timeline

Start
2009-03-02
Primary completion
2009-07-08
Completion
2009-07-08

Drugs

EvaluationDrugModalityDoseRoute
Subject Stable isotope tracer (13-C(4)-BHB) Unknown — Intravenous

Indications