Clobetasol Propionate 0.05% Shampoo in Association With Antifungal Shampoo in Scalp Seborrheic Dermatitis

Summary

The objective is to assess different treatment regimens with Clobetasol propionate shampoo 0.05% in the treatment of scalp Seborrheic Dermatitis.

Timeline

Start

2009-03

Primary completion

2010-02

Completion

2010-02

Outcome

Met primary endpoint

registry analysis (unspecified test); C Propionate 2/Week + Ketoconazole 2/Week vs Ketakonazol 2/Week; p <0.01; Cochran-Mantel-Haenszel NCT00862654 ↗

registry analysis (unspecified test); C Propionate 2/Week vs Ketakonazol 2/Week; p = 0.039; Cochran-Mantel-Haenszel NCT00862654 ↗

Publications

• Ortonne JP, Nikkels AF, Reich K, Ponce Olivera RM, Lee JH, Kerrouche N, Sidou F, Faergemann J. Efficacious and safe management of moderate to severe scalp seborrhoeic dermatitis using clobetasol propionate shampoo 0.05% combined with ketoconazole shampoo 2%: a randomized, controlled study. Br J Dermatol. 2011 Jul;165(1):171-6. doi: 10.1111/j.1365-2133.2011.10269.x.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Ketoconazole	Small molecule	2 %	Topical
Subject	clobetasol propionate	Small molecule	0.05 %	Topical

Indications