Sitagliptin Umbilical Cord Blood Transplant Study

Phase 2 Completed 29 enrolled Indiana University

Non-randomizedParallel-groupOpen-labelTreatment

Summary

The main purpose of this trial is to study whether the drug sitagliptin can be given safely to patients undergoing umbilical cord blood transplantation to speed up engraftment (recovery of blood counts after transplant).

Timeline

Start: 2009-03
Primary completion: 2012-11
Completion: 2015-02

Publications

Farag SS, Srivastava S, Messina-Graham S, Schwartz J, Robertson MJ, Abonour R, Cornetta K, Wood L, Secrest A, Strother RM, Jones DR, Broxmeyer HE. In vivo DPP-4 inhibition to enhance engraftment of single-unit cord blood transplants in adults with hematological malignancies. Stem Cells Dev. 2013 Apr 1;22(7):1007-15. doi: 10.1089/scd.2012.0636. Epub 2013 Feb 15.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Sitagliptin	Small molecule	600 mg	Oral

Sitagliptin Umbilical Cord Blood Transplant Study

Summary

Timeline

Publications

Drugs

Indications