Multiple Dose Effects of Hydrochlorothiazide and Isosorbide Mononitrate on Glucose Homeostasis (MK-0000-117)(Completed)

Summary

This study will measure and compare changes in insulin production and sensitivity using the hyperglycemic clamp technique in obese patients with impaired glucose tolerance and hypertension treated with placebo, isosorbide mononitrate (ISMN) or hydrochlorothiazide (HCTZ).

Timeline

Start

2009-03

Primary completion

2010-02

Completion

2010-03

Outcome

Missed primary endpoint

registry Hydrochlorothiazide (HCTZ) vs Hydrochlorothiazide (HCTZ) Placebo; p = 0.067 NCT00871871 ↗

registry Hydrochlorothiazide (HCTZ) vs Hydrochlorothiazide (HCTZ) Placebo; p >0.500 NCT00871871 ↗

registry Isosorbide Mononitrate (ISMN) vs Isosorbide Mononitrate (ISMN) Placebo; p = 0.342 NCT00871871 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hydrochlorothiazide	Unknown	50 mg	—
Subject	Isosorbide Mononitrate	Other / unclassified	60 mg	—

Indications