Safety, Tolerability And Pharmacokinetics Study Of Single Doses Of PNU-100480 In Healthy Adults

NCT00871949 ↗

Phase 1 Completed 19 enrolled Sequella, Inc.

RandomizedCrossoverDouble-blind

Summary

The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of PNU-100480 (PF-02341272) after a single dose in healthy adult volunteers.

Timeline

Start: 2009-04
Primary completion: 2009-08
Completion: 2009-08

Publications

Wallis RS, Jakubiec WM, Kumar V, Silvia AM, Paige D, Dimitrova D, Li X, Ladutko L, Campbell S, Friedland G, Mitton-Fry M, Miller PF. Pharmacokinetics and whole-blood bactericidal activity against Mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers. J Infect Dis. 2010 Sep 1;202(5):745-51. doi: 10.1086/655471.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Sutezolid	Small molecule	35 mg	Oral
Subject	Sutezolid	Small molecule	100 mg	Oral
Subject	Sutezolid	Small molecule	300 mg	Oral
Subject	Sutezolid	Small molecule	600 mg	Oral
Subject	Sutezolid	Small molecule	1000 mg	Oral
Subject	Sutezolid	Small molecule	1500 mg	Oral

Safety, Tolerability And Pharmacokinetics Study Of Single Doses Of PNU-100480 In Healthy Adults

Summary

Timeline

Publications

Drugs

Indications