Staccato Loxapine PK in Smokers and Nonsmokers

Phase 1 Completed 35 enrolled Alexza Pharmaceuticals, Inc.

Non-randomizedParallel-groupOpen-labelTreatment

Summary

The objective of this trial was to assess the pharmacokinetics of a single dose of 10 mg Staccato Loxapine administered to smokers compared to nonsmokers.

Timeline

Start: 2009-04
Primary completion: 2009-06
Completion: 2009-06

Publications

Background Takahashi LH, Huie K, Spyker DA, Fishman RS, Cassella JV. Effect of smoking on the pharmacokinetics of inhaled loxapine. Ther Drug Monit. 2014 Oct;36(5):618-23. doi: 10.1097/FTD.0000000000000048.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	loxapine	Small molecule	10 mg	Inhaled

Indications

No indication recorded.