Pharmacotoxicology of Trichloroethylene Metabolites

Summary

To establish the relationship between human MAAI haplotype and DCA and tyrosine metabolism. This aim test the postulates that MAAI haplotype determines, and thus can predict,1) dose-dependent DCA kinetics and biotransformation.

Timeline

Start

2009-08

Primary completion

2012-11

Completion

2012-11

Outcome

Met primary endpoint

registry analysis (superiority or other test); Lack Any EGT Allele on GSTz1/MAAI Region of Chromosome 14q24.3 vs 1+ EGT Allele on GSTz1/MAAI Region of Chromosome 14q24.3; p = 0.023 NCT00874276 ↗

Drugs

Indications