Vitamin D in Minorities With Prediabetes

Completed 117 enrolled Charles Drew University of Medicine and Science American Diabetes Association · collab

RandomizedParallel-groupDouble-blindPrevention

Summary

Vitamin D supplementation in minority subjects with both pre-diabetes and low vitamin D levels will delay the development of diabetes.

Timeline

Start: 2009-03
Primary completion: 2012-01
Completion: 2012-06

Outcome

Missed primary endpoint

registry Placebo vs Vitamin D; p = 0.61; NCT00876928 ↗

paper There were no differences between the placebo and vitamin D groups regarding fasting plasma glucose, 2-h glucose, or insulin secretion and sensitivity or in the percent developing diabetes PMID 23033239 ↗

Publications

Sinha-Hikim I, Duran P, Shen R, Lee M, Friedman TC, Davidson MB. Effect of long term vitamin D supplementation on biomarkers of inflammation in Latino and African-American subjects with pre-diabetes and hypovitaminosis D. Horm Metab Res. 2015 Apr;47(4):280-3. doi: 10.1055/s-0034-1383652. Epub 2014 Jul 10.
Davidson MB, Duran P, Lee ML, Friedman TC. High-dose vitamin D supplementation in people with prediabetes and hypovitaminosis D. Diabetes Care. 2013 Feb;36(2):260-6. doi: 10.2337/dc12-1204. Epub 2012 Oct 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Vitamin D	Other / unclassified	—	—